Increased lipogenesis in cancer
نویسندگان
چکیده
منابع مشابه
Lipogenesis in cancer progression (review).
In normal tissues, energy-providing lipids come principally from circulating lipids. However, in growing tumors, energy supply is mainly provided by lipids coming from de novo synthesis. It is not surprising to see elevated expression of several lipogenic genes in tumors from different origins. The role of lipogenic genes in the establishment of the primary tumor has been clearly established. A...
متن کاملIncreased lipogenesis in isolated hepatocytes from cold-acclimated ducklings.
Thermogenic endurance and development of metabolic cold adaptation in birds may critically depend on their ability to synthesize and use fatty acids (FA) as fuel substrates. Hepatic lipogenesis and the capacity to oxidize FA in thermogenic tissues were measured in cold-acclimated (CA) ducklings (Cairina moschata) showing original mechanisms of metabolic cold adaptation in the absence of brown a...
متن کاملLPA activates lipogenesis in ovarian cancer cells
One of the most common molecular changes in cancer is the increased endogenous lipid synthesis, mediated primarily by overexpression and/or hyperactivity of fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC). The changes in these key lipogenic enzymes are critical for the development and maintenance of the malignant phenotype. Previous efforts to control oncogenic lipogenesis have been ...
متن کاملTargeting lipogenesis in the treatment of metabolic diseases and cancer
Lipogenesis must be regulated tightly to meet metabolic needs according to nutritional status. During fasting, fatty acid synthesis is virtually absent mainly due to increased glucagon/cAMP signaling [1]. In contrast, during feeding, fatty acid synthesis mainly in liver increases drastically, especially when the diet is carbohydrate rich, as glucose utilization and glycolysis increase [2]. Incr...
متن کاملIncreased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity.
To determine whether increased lipogenesis contributes to human obesity, we measured (postabsorptive state), in lean and obese subjects, lipid synthesis (deuterated water method) and the mRNA concentration (RT-competitive PCR) in subcutaneous adipose tissue of fatty acid synthase (FAS) and sterol regulatory element-binding protein (SREBP)-1c. Before energy restriction, obese subjects had an inc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Communicative & Integrative Biology
سال: 2009
ISSN: 1942-0889
DOI: 10.4161/cib.2.6.9343